胆固醇栓塞综合征

Cholesterol embolization syndrome

胆固醇栓塞综合征是大动脉血管壁上动脉粥样硬化斑块破裂,斑块内胆固醇结晶脱落至远端小动脉造成栓塞而引起的。胆固醇栓塞综合征常引起栓塞部位的炎症反应,并造成终末靶器官的损伤。最常受累的靶器官为脑、肾、消化道、皮肤和下肢骨骼肌等。诊断须依据症状、体征和实验室检查(嗜酸粒细胞增多)。他汀类药物、抗血小板药物、在易损斑块处安放支架等是目前治疗胆固醇栓塞综合征的主要手段。

Cholesterol embolization syndrome is caused by rupture of atherosclerotic plaque of large artery endothelium, embolism of cholesterol crystals in distal arteries. Cholesterol embolization syndrome often cause inflammatory response in embolization region, and cause end-organ damage. Most often involved organs are brain, kidney, gastrointestinal tract, skin and skeletal muscles of the lower extremities. The diagnosis of cholesterol embolization may depend on symptoms, signs and laboratory examinations （hypereosinophilia）. Statins, antiplatelet drugs, and stents in vulnerable plaque are nowadays the main strategies for treatment of cholesterol embolization syndrome.