过敏性紫癜患者血清中TRANCE和BLys的检测

Serum Level of TRANCE and BLys and Their Significance in Patients with Anaphylactoid Purpura

目的了解TRANCE和BLys在过敏性紫癜发病中的作用。方法通过酶联免疫吸附试验(ELISA)检测过敏性紫癜患者血清中TRANCE和BLys的表达水平。结果过敏性紫癜患者血清中TRANCE和BLys的表达水平(2.83±0.96,90.48±2.64)与正常对照组(0.85±0.35,82.02±4.04)相比均升高(P<0.01),伴有肾脏损害患者血清中TRANCE,BLys的表达水平(4.09±0.45,93.92±2.07)与单纯型患者(2.44±0.70,89.42±1.75)相比显著增高(P<0.01)。患者血清中TRANCE与BLys的表达水平呈显著正相关(r=0.515,P<0.01)。结论过敏性紫癜患者血清中TRANCE,BLys的表达异常增高,可能与其发病有关。

Objective To detect the level of TRANCE and BLys in serum of patients with anaphylactoid purpura.Methods The TRANCE and BLys level in serum of patients with anaphylactoid purpura were detected by ELISA（enzyme-linked immunosorbent assay,ELISA）.Results TRANCE and BLys expression level in anaphylactoid purpura patients serum（2.83±0.96,90.48±2.64）were significantly higher than that in normal control groups（0.85±0.35,82.02±4.04）（P〈0.01）.TRANCE and BLys expression level in anaphylactoid purpura with kidney damage patients serum（4.09±0.45,93.92±2.07） were significantly higer than that in anaphylactoid purpura without kidney damage patients serum（2.44±0.70,89.42±1.75）（P〈0.01）.TRANCE and BLys expression level in anaphylactoid purpura patients serum was a significantly positive correlation（P〈0.01）.Conclusion TRANCE and BLys expression level in serum of patients with anaphylactoid purpura was higher,which may be involved in the formation of anaphylactoid purpura.