5-氨基酮戊酸光动力疗法治疗中、重度痤疮临床观察

Clinical Observation of ALA-PDT for Moderate to Severe Acne Vulgaris

目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中、重度痤疮的临床疗效。方法治疗组26例,予ALA-PDT照射20min,1次/周;对照组20例,予蓝光照射20min,1次/周,同时予口服维胺酯胶囊25mg和外擦克林霉素软膏,2次/d。两组疗程均为4周,并于治疗前及治疗第2,4和6周时判定疗效。结果治疗第4周时,治疗组中、重度痤疮患者的有效率(89.47%和71.43%)分别高于对照组(60.00%和0),差异均有统计学意义(P均<0.05);治疗第6周时,治疗组痊愈率(42.31%)和有效率(92.31%)明显优于对照组(10.00%和55.00%)。结论 ALA-PDT是一种安全、高效和不良反应轻微的治疗中、重度痤疮的新方法。

Objective To observe the clinical efficacy of ALA-PDT for treatment of moderate to severe ache vulgaris. Methods Twenty-six cases were assigned to the trail group, and treated by ALA-PDT weekly, twenty mi- nutes for each time; 20 cases were assigned to the control group, and treated by blue light weekly, twenty minutes for each time. Meanwhile the control group were treated viaminate capsules 25mg orally and topic clindamycin ointment, twice a day. Course of treatment in both group were 4 weeks. To evaluate the clini- cal efficacy of pre and post treatment （2rid, 4th, 6th week）. Results On the 4th week, the effective rate （ 89.47% and 71.43% ） of moderate to severe ache vulgaris in the trail group, was higher than that of the control group（60.00% and 0 ） , The difference was statistically significant（ all P 〈 0.05 ） ; On the 6th week, the cure rate （42.31% ） and effective rate （ 92.31% ） of trail group was higher than that of control group（cure rate 10.00% , effective rate 55.00% ）. Conclusion Due to safety, effectiveness and mild adverse reaction, ALA-PDT might become a new method in the treatment of moderate to severe ache vul- garis.