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涎腺肿瘤组织TN-CmRNA和CD9mRNA的表达及其意义

Expressions of TN-CmRNA and CD9mRNA in Salivary Gland Tumors
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摘要 目的:探讨Tenascin-C(TN-C)mRNA和CD9mRNA在涎腺肿瘤的表达及其对涎腺肿瘤鉴别诊断的价值。方法:采用原位杂交技术检测10例正常涎腺组织、25例多形性腺瘤(PA)、25例腺样囊性癌(ACC)、20例黏液表皮样癌(MEC)、10例腺泡细胞癌(ACCa)中TN-CmRNA和CD9mRNA的表达。结果:TN-CmRNA在正常涎腺组织中呈阴性表达;CD9mRNA在正常涎腺组织中的阳性率为100%;TN-CmRNA、CD9mRNA在4种涎腺肿瘤中均有表达,TN-CmRNA在多形性腺瘤中的阳性表达率显著高于腺样囊性癌和黏液表皮样癌,差异具有统计学意义,而在多形性腺瘤与腺泡细胞癌中的表达差异无统计学意义。CD9mRNA在多形性腺瘤中的阳性表达率高于腺样囊性癌,差异有统计学意义,而在多形性腺瘤和黏液表皮样癌、腺泡细胞癌中的表达差异无统计学意义;在多形性腺瘤中TN-CmRNA和CD9mRNA的表达呈正相关,在腺样囊性癌、黏液表皮样癌和腺泡细胞癌中TN-CmRNA和CD9mRNA的表达无相关性。结论:TN-CmRNA和CD9mRNA与涎腺肿瘤的发生有一定相关性,对涎腺肿瘤之间的鉴别诊断有一定意义。 Objective： To study the relationship between TN-C mRNA, CD9 mRNA and salivary gland tumors, and their potential role in the differential diagnosis of salivary gland tumors. Methods： The technique of in situ hy- bridization was used to detect the expressions of TN-C mRNA and CD9 mRNA in 10 normal saliary gland, 25 ple- omorphic adenoma, 25 adenoid cystic carcinoma, 20 mucoepidermoid carcinoma and 10 acinic cell carcinoma. Re- suits： TN-CmRNA was negative in normal salivary gland, but CD9 mRNA was 100 % positive. The expressions of TN-C mRNA and CD9 mRNA in the four kinds of salivary gland tumors were all observed. The positive rate of TN-C mRNA in pleomorphic adenoma was significantly higher than that of adenoid cystic carcinoma and mucoepi- dermoid carcinoma （P〈0.05）. But there was no difference between pleomorphic adenoma and acinic cell carcino- ma. The positive rate of CD9 mRNA in pleomorphic adenoma was significantly higher than that of adenoid cystic carcinoma （P〈 0. 05）. There was no difference between pleomorphic adenoma and mucoepidermoid carcinoma, acinic cell carcinoma. There was a positive correlation between the expression of CD9 mRNA and TN-C mRNA in pleomorphic adenoma, but there was no correlation in adenoid cystic carcinoma, mucoepidermoid carcinoma and acinic cell carcinoma. Conclusion： There were a correlation between TN-C mRNA, CD9 mRNA and salivary gIand tumors and ther was some significance of differential diagnosis in salivary gland tumors.
作者 郭康 李文才
机构地区 郑州大学第一附属医院病理科
出处 《口腔医学研究》 CAS CSCD 2012年第5期400-404,共5页 Journal of Oral Science Research
关键词 TN-C CD9原位杂交涎腺肿瘤 TN-C CD9 In situ hybridization Salivary gland tumors
分类号 R739.8 [医药卫生—肿瘤]
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口腔医学研究
2012年 第5期

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