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BTLA信号通路在免疫调节中的作用 被引量：1

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摘要 BTLA(CD272)属于免疫球蛋白超家族成员,广泛表达于免疫细胞,其配体为HVEM。BTLA基因敲除小鼠淋巴器官发育基本正常,但TCR诱导的免疫应答反应显著增强,CD8记忆T细胞数量显著增多;抗原特异性IgG反应增强,并逐步出现自身抗体、高丙球蛋白血症以及自身免疫性肝炎样疾病。这些结果证明,BTLA具有抑制细胞及体液免疫反应的功能。BTLA信号通路与部分自身免疫性疾病、艾滋病等感染性疾病、肿瘤和移植物抗宿主病等的发生和发展密切相关,调控BTLA信号通路有望用于相关疾病的免疫治疗。
作者 程小星 蒋静
机构地区 解放军第
出处 《现代免疫学》 CAS CSCD 北大核心 2012年第3期257-260,共4页 Current Immunology
基金 国家自然科学基金资助项目(81071318)
关键词 BTLA 辅助刺激分子受体 免疫调节 免疫治疗
分类号 R392.12 [医药卫生—免疫学]
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参考文献27

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二级参考文献31

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现代免疫学
2012年 第3期

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