摘要
目的探讨葛根素对糖尿病大鼠心功能及心肌细胞内钙离子的影响。方法 40只SD大鼠随机分成空白对照组、糖尿病模型组、葛根素低剂量组和葛根素高剂量组,每组10只。测定大鼠心脏功能、心室重量指数、心脏重量指数和心肌细胞内钙离子瞬间变化。结果与糖尿病模型组比较,葛根素低剂量组和葛根素高剂量组心脏功能明显改善,心室重量指数、心脏重量指数及钙瞬变峰幅度下降,钙瞬变时程缩短,且高剂量组改善更加明显。结论葛根素可以改善糖尿病大鼠心功能、心室重量指数和心脏重量指数,其机制可能与调节心肌细胞内钙离子水平有关。
Aim To investigate the effects of puerarin on ventricular function and calcium levels in diabetic rats.Methods Forty SD rats were randomly divided into four groups： the control group,the diabetic model group,the puerarin low dose group and high dose group.The cardiac function,ventricular mass index,heart weight index and calcium levels were respectively measured.Results Compared with diabetic model group,in the puerarin low dose group and high dose group cardiac function was significantly improved,ventricular mass index,heart weight index and calcium levels were decreased,but the puerarin high doses group improved more significantly.Conclusions Puerarin can improve cardiac function,ventricular mass index,heart weight index in diabetic rats,and its mechanism may be related to intracellular calcium levels.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第6期532-535,共4页
Chinese Journal of Arteriosclerosis
关键词
葛根素
糖尿病
心功能
钙离子
Puerarin
Diabetes
Cardiac Function
Calcium
