急性心肌梗死患者血浆sST2水平与冠状动脉病变程度的相关性

Association Between Level of Plasma Soluble ST2 and Degrees of Coronary Artery Stenosis in Acute Myocardical Infarction

目的探讨急性心肌梗死患者血浆白细胞介素1受体家族成员sST2浓度与冠状动脉狭窄严重程度的关系及意义。方法选择发病12 h内急诊经皮冠状动脉介入术术前的急性心肌梗死患者44名,采用酶联免疫吸附法检测患者血浆sST2浓度,根据造影结果对冠状动脉狭窄程度进行Gensini评分。分析sST2水平与冠状动脉病变程度和病变支数的关系。结果急性心肌梗死患者血浆中sST2水平随着冠状动脉Gensini评分增高而逐渐升高(P<0.001)。多支冠状动脉病变组血浆sST2浓度显著高于单支病变组(P<0.01)。sST2浓度与冠状动脉Gensini评分呈显著正相关(r=0.772,P<0.001)。结论急性心肌梗死患者血浆sST2水平可能成为预测冠状动脉狭窄严重程度的标志物。

AimThe study was designed to investigate the association between plasma concentrations of the soluble interleukin-1 receptor family member ST2（sST2） and the degree of coronary artery stenosis in patients with acute myocardical infarction（AMI）.Methods Plasma soluble ST2 levels were measured via enzyme-linked immunosorbent assay（ELISA） in 44 AMI patients within 12 hours of the onset.The levels of coronary stenosis were assessed by Gensini scores and numbers of diseased vessels were counted.The association between plasma soluble ST2 level and coronary artery stenosis degree was analysed by SPSS software.Results In AMI patients,the plasma sST2 was increased significantly in high Gensini scores subgroup（P0.001） and a positive relation was found between sST2 levels and Gensini scores（r=0.772,P0.001）.The plasma sST2 level was also significantly higher in patients with multivessels compared with single vessel（P0.01）.ConclusionThe levels of plasma soluble ST2 was positively correlated with severity of coronary stenosis and may predict the degrees of coronary stenosis in AMI patients.