易损斑块的血清标记物研究进展

Research Progress on Inflammatory Biomarkers of Vulnerable Plaques

临床研究证实炎症在动脉粥样硬化损伤的各阶段均有重要作用,包括从脂纹形成到最终易损斑块的破裂。炎症标记物可以反映与急性冠状动脉综合征的各个阶段相关联的动脉粥样硬化进程的不同侧面,还可能与急性冠状动脉综合征的严重性有关。该综述总结了有关炎症标记物的文献,为使用炎症标记物检测易损斑块的可行性提供了一些证据。这些证据可能会促使动脉粥样硬化患者的管理更加完善,包括一级预防和二级预防。

Clinical studies showed inflammation plays a great role in all phases of the development of atherosclerotic lesions,from the fatty streak lesion formation to the eventual rupture of the vulnerable plaque.Inflammation biomarkers may reflect different aspects of the atherothrombotic process in relation to the stages of acute coronary syndrome,and may correlate with its severity.This review summarizes the literature on the role of biomarkers of the atherosclerotic plaque with a view to suggest some evidence of feasibility for identification of vulnerable plaques.These evidence may encourage patients with atherosclerosis with more perfect management,involved both primary and secondary prevention.