摘要
目的:检测寻常性银屑病(psoriasis vulgaris,PV)患者血清白介素(IL)-21的水平,并探讨其与银屑病皮损面积和严重度指数(PASI)评分之间的相关性。方法:采用酶联免疫吸附法(ELISA)比较37例PV患者(患者组)和37例健康对照者(健康对照组)血清IL-21的水平,并结合患者的PASI评分进行统计学相关性分析。结果:PV患者组血清IL-21水平高于健康对照组(t=2.873,P<0.01),患者组血清IL-21水平与其PASI评分呈显著正相关(r=0.471,P<0.01)。结论:PV患者组血清IL-21水平升高,且与疾病严重程度呈显著正相关,提示IL-21可能在PV的发病中发挥重要作用。
Objective: To detect serum interleukin-21 (IL-21) levels in patients with psoriasis vulgaris (PV) and investigate the correlation between serum IL-21 levels and PASI scores. Methods: Serum IL-21 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 37 cases of PV and 37 healthy controls. PASI scores in patients with PV were also evaluated. Results: (1) Serum IL-21 levels were higher in PV patients than those in healthy control subjects (t = 2.873, P〈 0.01). (2) Serum IL-21 levels in PV patients positively correlated with PASI scores (r=0.471, P〈0.01). Conclusions: Serum IL-21 levels in patients with PV are elevated and positively correlate with disease severity. The results suggest that IL-21 may play an important role in the pathogenesis of PV.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2012年第6期346-348,共3页
Journal of Clinical Dermatology