细胞集落刺激因子诱导肺癌干细胞分化的临床应用

Application of inducing the stem cell of lung cancer with cell colony stimulating factor

目的诱导肺癌干细胞进入分裂期以提高对化疗药物的敏感度。方法未手术晚期肺腺癌患者115例随机分为诱导化疗组(试验组)和常规化疗组(对照组)。两组均予以长春瑞滨+顺铂(NP)方案化疗;试验组化疗期间加用重组人粒细胞集落刺激因子(rhG-CSF)诱导肺癌干细胞分化。化疗2个周期后2周比较两组的疗效。结果试验组近期有效率明显高于对照组(61.8%vs.41.5%)(P<0.05)。结论通过诱导肺癌干细胞向相应的成熟细胞分化使其对化疗敏感,可以提高治疗效果。

Objective To induce the lung cancer stem cell into dividing phase for improving the sensibility to chemotherapeutics. Methods A total of 115 patients with advanced and inoperatable lung adencarcinoma was randomly divided into two groups of A（treated with conventional chemotherapy of navelbine and DDP） and B（treated with additional recombinant humam granulocyte colony-stimulating factor to induce tumor stem cell differentiation）.The curative effect and side effect were compared two weeks after two cycles of chemotherapy. Results The short-term effectiveness rate was higher in group B than that in group A（61.8% vs.41.5%）（P0.05）. Conclusion To make an increase of the sensibility of lung adencarcinoma to chemotherapeutics may enhance the therapeutic efficacy.