2，4-二羟基苯甲酰腙Cu(Ⅱ)配合物的合成、表征及其与DNA的相互作用研究

Synthesis,Charaterization and DNA Interactions of 2,4-Dihydroxybenzoylhydrazone Coordinated to Cu(Ⅱ)

合成了2,4-二羟基苯甲醛缩对硝基苯甲酰腙Cu(Ⅱ)配合物,通过红外、紫外、X-射线单晶衍射对其组成结构进行了表征。配合物属单斜晶系,C2/c空间群,晶胞参数为a=1.573 6(3)nm,b=0.715 82(14)nm,c=3.171 2(6)nm,β=96.631(3)°,V=3.548 3(12)nm3,Z=4,Dc=1.639 g.cm-3。配合物通过弱的分子间氢键C-H…O构筑三维结构。利用溴化乙锭(EB)荧光猝灭分析法研究了其与小牛胸腺DNA(ct-DNA)的相互作用。结果说明配合物与ct-DNA可能发生插入作用,是潜在的抗癌药物。

Cu（Ⅱ） complex derived from 2,4-dihydroxybenzaldehyde p-nitrobenzoylhydrazone was synthesized and characterized by IR, UV-Vis and X-ray single crystal diffraction respectively. The complex crystallizes in monoclinic, space group C2/c with cell parameter a=1.573 6（3） nm, b=0.715 82（14） nm, c=3.171 2（6） nm, β=96.631（3）°; V=3.548 3（12） nm3, Z=4, Dc=1.639 g·cm^-3. The complex forms 3D structure through weak hydrogen bonds C-H…O. The interaction of complex with calf thymus （CT） DNA was studied by ethidium bromide （EB） fluorescence spectroscopy. The result indicates that the interaction of this complex with ct-DNA may be intercalation, and the complex may be used as a potential antitumor drug. CCDC： 836564.