七叶洋地黄双苷滴眼液对不同年龄段人工晶状体眼伪调节力的影响

Effect of esculin and digitalisglycosides eye drops on pseudo-accommodation of intraocular lens eye with different ages

目的研究七叶洋地黄双苷滴眼液对不同年龄段人工晶状体眼伪调节力的影响。方法选取2010年9月至2011年8月在我院行白内障超声乳化吸出联合单焦点人工晶状体植入术患者56例(60眼),随机分为2组(试验组30例、对照组26例),每组各30眼。试验组术后应用七叶洋地黄双苷滴眼液和双氯芬酸钠滴眼液滴眼,每天3～4次;对照组术后仅使用双氯芬酸钠滴眼液滴眼,每天3～4次。分别在术前、术后1周、4周检查患者的裸眼远视力、近视力、最佳矫正远视力下的近视力、矫正状态下的近视力,应用负镜片法测量人工晶状体眼的调节幅度,并对各项指标对比分析。结果试验组各年龄段人工晶状体眼术后4周的最佳矫正远视力为0.83±0.19,对照组最佳矫正远视力为0.81±0.16,2组比较差异无统计学意义(P>0.05);试验组最佳矫正远视力下的近视力为0.31±0.05,对照组的最佳矫正远视力下的近视力为0.20±0.05,2组比较差异有统计学意义(P<0.05)。术后4周,试验组各年龄段的人工晶状体眼的伪调节力均高于对照组,差异均有统计学意义(均为P<0.05),试验组各年龄段人工晶状体眼的伪调节力的影响与年龄增长呈负相关(r=-0.312)。结论七叶洋地黄双苷滴眼液可以增加人工晶状体眼的有效伪调节力,七叶洋地黄双苷滴眼液对人工晶状体眼的伪调节力的影响与年龄呈负相关关系。

Objective To study the effect of esculin and digitalisglycosides eye drops on pseudo-accommodation of intraocular lens eye with different ages.Methods Fifty-six patients（60 eyes） that underwent phacoemulsification and monofocal intraocular lens implantation from September 2010 to August 2011 in our hospital were chosen and randomly divided into experimental group（30 cases,30 eyes） and control group（26 cases,30 eyes）.The patients in experimental group after surgery received esculin and digitalisglycosides and diclofenac sodium eye drops,and the control group only received diclofenac sodium eye drops,3-4 times per day in all patients.The uncorrected distant visual acuity,near visual acuity,near visual acuity under best corrected distant visual acuity and corrected near visual acuity before surgery and 1 week,4 weeks after surgery were examined,the amplitude of accommodation was measured by a negative lens-shift method,and the indexes were statistical analyzed.Results The best corrected distant visual acuity at 4 weeks after surgery in experimental group of all ages was 0.83± 0.19,which in control group was 0.81±0.16,there was no statistical difference（P0.05）.The near visual acuity under best corrected distant visual acuity in experimental group was 0.31±0.05,which in control group was 0.20±0.05,there was statistical difference（P0.05）.At 4 weeks after surgery,the pseudo-accommodation power of intraocular lens in experimental group of all ages were higher than that in control group,there were statistical differences（both P0.05）,and the effect of esculin and digitalisglycosides eye drops on pseudo-accommodation power in experimental group of all ages were negative correlated with age（r=-0.312）.Conclusion Esculin and digitalisglycosides eye drops can increase the effective pseudo-accommodation of intraocular lens eye,and the effect of esculin and digitalisglycosides eye drops on pseudo-accommodation power is negative correlated with age.