视网膜色素变性治疗的研究进展

Recent advances in retinitis pigmentosa therapy

视网膜色素变性(retinitis pigmentosa,RP)是由视网膜光感受器和视网膜色素上皮变性所引起的致盲性、遗传性眼病,目前尚无有效的治疗方法,相关治疗研究还处于探索阶段,如基因治疗、药物治疗、移植治疗、人工视网膜假体等。基因治疗RP是目前的研究热点,包括修复致病基因、核酸治疗、RNA干扰技术等。基因治疗、干细胞移植、人工视网膜假体治疗RP已经进入临床试验阶段,为治疗该病带来了新的希望。本文就RP治疗的研究进展做一综述。

Retinitis Pigmentosa（RP） is a heterogeneous group of inherited retinal disorders characterized by photoreceptor or retinal pigment epithelial degeneration and apoptosis.At present,there is no clinically effective treatment for RP,and it becomes the hot issue in international research.Current treatment for RP is still in the exploratory research period,including gene therapy,pharmacologic treatment,transplantation treatment and neuro-prosthetic devices.Gene therapy for RP is the hot spot,including repair disease genes,nucleic acid therapy,RNA interference technology and other methods.Those methods have entered the clinical trials stage,which bring new hopes for the treatment of RP.This article reviews the recent advances in treatment of RP.