肠道NK/T细胞淋巴瘤4例诊治分析

Intestinal primary malignant NK/T-cell lymphoma: report of four cases

目的:探讨肠道NK/T细胞淋巴瘤的临床特点、诊断及治疗。方法:回顾性分析4例肠道NK/T细胞淋巴瘤的临床资料,对其发病特点、临床表现、实验室检查、诊断和治疗方法进行总结分析。结果:3例为小肠NK/T细胞淋巴瘤,CD45RO(+),CD3(+),CD56(+),CD20(-),TIA(-)。1例为结肠NK/T细胞淋巴瘤,CD45RO(+),CD3(+),CD56(+),CD20(-),TIA(+)。4例患者术后分别存活61、58、14、7 d。结论:肠道NK/T细胞淋巴瘤确诊需依赖术后病理组织学及免疫组织化学检查,早期诊断、尽早实施合理的治疗是降低死亡率的关键。

Objective： To study the clinical features, diagnosis and treatment of intestinal pri- mary malignant NK/T-cell lymphoma. Methods： The clinical data of 4 patients with primary malig- nant NK/T-cell lymphoma in the intestine admitted to our hospital from 1998 to 2008 were viewed. Results： Three cases were diagnosed as primary malignant NK/T-cell lymphoma in small intestine and 1 case was in colon by pathology. All 4 cases died respectively, 61,58,14 and 7 days after exploratory surgery ,of possible recurrent perforation. Conclusion： Postoperative pathology and immunohistochemical examination remain the mainstay for final diagnosis. The prognosis is dependent on early diagnosis and treatment.