OOC患者血清胆囊收缩素与直肠肛管压力的相关性研究

Role of anorectal pressure and blood cholecystokinin abnormality in outlet obstructive constipation and the relationship between them

目的:研究直肠肛管压力及血清胆囊收缩素(CCK)的改变在功能性出口梗阻型便秘(OOC)患者发病中的作用。方法:采用四通道环状固态压力传感器测压导管测定50例OCC患者直肠肛管压力;采用酶联免疫吸附测定(ELISA)检测其中20例血清CCK水平,并与20例正常人做对照。结果:与正常对照组相比,OCC患者的肛管静息压、最大缩榨压明显降低,引起直肠初始感觉、初始便意感觉和最大感觉阈值的容积均明显升高(P值均<0.01)。OCC组血清CCK水平显著低于正常对照组,与最大感觉阈值呈负相关。结论:OCC患者存在直肠肛管压力异常、直肠感觉功能下降及血清CCK的异常。直肠容量的感知能力与血清CCK含量呈负相关。

Objective： To investigate the role and relationship of anorectal pressure and blood cholecystokinin （CCK~ abnormality in outlet obstructive constipation （OOC）. Methods： Anorectal pressure was measured with anorectal catheta of solid srate manometric transducers,and 50 pa- tients with OOC were comparatively investigated. Using enzyme-linked immunosorbent assay （ELISA）, we measured the serum CCK of the 20 healthy controls and the 20 patients randomly selected from above 50 patients. Results： The anal sphincter resting pressure （ARP） and the maximum squeeze pressure（MSP） in QQC group （128.65mmHg ＋36.04mmHg） was lower than that in control group （151.47mmHg ＋ 12.06mmHg）. The first sensitive volume （FSV）, defecate sensitive volume （DSV） and maximum tolerable volume （MTV） in OOC group were higher than those in control group （P〈0.01）. CCK was lower than control group and had negatively correlated with the MTV. Conclusion： Anorectal pressure, rectal sensation function and CCK were abnormal in patients with OOC. The rectal sensation function was negatively correlated with the CCK.