降钙素对骨质疏松性骨内种植体骨生物力学性能的影响

Effect of calcitonin on biomechanical characteristics of osteoporotic bone with implant

目的探讨降钙素对骨质疏松症兔胫骨植入种植体后生物力学性能的影响。方法将72只健康新西兰雌兔随机平分为3组,其中2组经过卵巢切除形成骨质疏松症兔,再随机分为降钙素实验组(CT组)和骨质疏松症对照组(OP组);第3组为正常对照组(NC组)。各组兔胫骨内植入纯钛螺纹状种植体,其中,CT组以降钙素治疗,其它2组用生理盐水治疗。各组分别于第2、4、8周后获取8个标本,行生物力学性能测定。结果第2、4、8周时,各组平均弯曲破坏载荷(bend load,BL)为:NC组>CT组>OP组,差异有统计学意义(P<0.01);各组平均最大拉伸长度(maxillary tensile length,TLmax)为:NC组<CT组<OP组,差异均有统计学意义(P<0.01)。结论降钙素对骨质疏松症有治疗作用,且能提高骨质疏松症骨的生物力学性能。

Objective To investigate the effect of calcitonin on biomechanical characteristics of osteoporotic bone with implant.Methods The osteoporosis model was induced by ovariectomy in female New Zealand rabbits.Seventy-two rabbits were randomly divided into three groups with 24 in each group： in normal control group（NC） animals received intramuscular injection of normal saline 0.4ml/d×4d,in osteoporosis group（OP） a pure titanium screw was implanted in the proximal tibial metaphysis in castrated animals and received intramuscular injection of normal saline,in calcitonin group（CT） the animals received both titanium implant and intramuscular injection of calcitonin 4u/d×4d.Eight specimens were harvested from each group at week 2,4 and 8;biomechanical characteristics including bend load（BL） and maxillary tensile length（TL max） were evaluated.Results The BL in NC group was highest,followed by CT group,and that in OP group was lowest at all time points.The TL max of NC group was shortest,followed by CT group,and that of OP group was longest at all time poits.There were significant differences among these groups（P0.01）.Conclusion Calcitonin can improve the biomechanical characteristics of osteoporotic bone with implant.