男性乳腺癌预后的单中心分析

Prognosis of Male Breast Cancer at A Single Institution

目的初步探讨影响男性乳腺癌患者预后的因素。方法收集2003年1月-2011年12月经病理确诊、接受治疗、临床资料较完整的36例男性乳腺癌患者的临床资料。采用对数秩检验和Cox回归分析影响男性乳腺癌患者预后的因素。结果 36例患者无进展生存期(PFS)为3～95个月,中位PFS为45个月。单因素分析显示:肿瘤直径(P=0.001)、阳性淋巴结(P=0.001)、TNM分期(P<0.001)、手术方式(P=0.001)是影响预后的因素。多因素分析显示:阳性淋巴结(P=0.024)和TNM分期(P=0.022)是影响预后的主要因素。结论阳性淋巴结和TNM分期是影响预后的主要因素,以手术为主的综合治疗模式是提高男性乳腺癌患者生存率的重要措施。

Objective To investigate the prognostic factors of Chinese patients with male breast cancer（MBC） based on the data from a single institute with a relatively large sample.Methods Clinical data of 36 patients with histopathologically confirmed MBC who received treatment between January 2003 and December 2011 were collected.Log-rank test and Cox regression model were used for statistical analysis.Results Progress free survival（PFS） were 3-95 months,median PFS was 45 months.Univariate analysis showed that tumor size（P=0.001）,axillary lymph node status（P=0.001）,TNM stage（P〈0.001）,operation model（P=0.001） significantly influenced the survival.Multivariate analysis showed that axillary lymph node status（P=0.024） and TNM stage（P=0.022） were the significant prognostic factors for MBC.Conclusions Axillary lymph node status and TNM stage are the significant prognostic factors for MBC.Radiotherapy could improve the local control rate of MBC.Comprehensive treatment mode with operation is essential to improve the survival of patients with MBC.