重症急性胰腺炎并发多器官功能障碍及预后关系的临床研究

The Clinical Research on the Concurrent Severe Acute Pancreatitis and Multiple Organ Dysfunction and Its Prognosis

目的探讨重症急性胰腺炎并发多器官功能障碍及预后关系的临床研究。方法回顾分析2008年1月-2010年12月收治的51例重症急性胰腺炎患者的临床资料。结果其中出现全身炎症反应综合征者46例(90.20%),多器官功能障碍36例(70.59%),重症急性胰腺炎并发多器官功能障碍者治愈好转20例,未合并者治愈好转13例。死亡18例。结论引起重症急性胰腺炎患者死亡的最主要因素是多器官功能障碍,早预防、早发现、综合治疗多器官功能障碍有助于降低重症急性胰腺炎患者死亡率。

Objective To explore the concurrent severe acute pancreatitis（SAP） and multiple organ dysfunction（MODS） and its prognosis.Methods The clinical data of 51 patients with SAP who were admitted to our hospital between January 2008 and December 2010 were retrospectively analyzed,and the clinical features were summarized.Results Forty-six（90.20%） out of the 51 patients had systemic inflammatory response syndrome（SIRS）,36（70.59%） had multiple organ dysfunction,and 18（35.29%） died.Conclusions The most important factor of causing the death of the patients with SAP is MODS.Early prevention and diagnosis,and integrated therapy are helpful in reducing mortality of SAP with MODS.