晚期食管癌2种化疗方案疗效对比观察

Two regimens for chemotherapy of advanced esophageal cancer in comparison

目的:观察DF/TP方案化疗晚期食管癌疗效。方法:按治疗方案将患者分为A、B两组,A组予DF(DDP 20mg/m2,d1-5;5-FU 0.5g/m2,d1-5)化疗,有效者(CR/PR)共3-4个周期,化疗2周期未达PR改用TP方案化疗2周期;B组予TP(TAX 175mg/m2,d1,DDP 30mg/m2,d1、2、3)方案化疗,有效者(CR/PR)共3-4个周期,化疗2周期未达PR改用其他治疗方案。结果:两组有效率相近(P﹥0.05),无显著差异;恶心、呕吐、胆红素、转氨酶毒性无显著差异(P﹥0.05);白细胞与血红蛋白毒性、脱发、神经毒性有显著差异(P<0.05);TP方案对DF方案化疗进展或无效者有效率21.05%;DF方案中位进展期3个月,TP方案中位进展期4个月。结论:TP方案二线使用更有优势。

Objective：To observe the effect of the chemotherapy with DF or TP regimen for advanced esophageal cancer.Methods：Group A： patients were treated with DF regimen（DDP 20mg/m2 d1-5,5-FU 0.5g/m2 d1-5）.Patients who were effective（CR or PR） were treated continued with the treatment for 3 to 4 cycles.Patients who were not effective（PR） after 2 chemotherapy cycles were administered with TP（TAX 175mg/m2,d1,DDP 30mg/m2,d1,2,3） regimen for 2 cycles;Group B： patients were treated with TP regimen（TAX 175mg/m2,d1,DDP 30mg/m2,d1,2,3）.Patients who were effective（CR or PR） were continued treatment for 3 to 4 cycles.Patients who were not effective（PR） after 2 chemotherapy cycles were administered with other regimen.Results：The effective rate of the two groups of initial treatment was not different（P〉0.05）.Incidences of nausea and vomiting and toxicity of bilirubin and transaminase were not different（P〉0.05）,but the toxicity of leucocyte and hemoglobin and hair and nerve was different（P〈0.05）.The TP regimen was effective to patients who were worsened or ineffective and their effective rates were 21.05% respectively.Median time to progression was 3 months with DF regimen of initial treatment.Median time to progression was 4 months with TP regimen of initial treatment.Conclusion：There was more advantage in the TP regimen as second-line therapy for advanced esophageal cancer.