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辅助性T细胞17(Th17)的特征及其在自身免疫性疾病中的作用 被引量：3

The features of T helper 17 cell(Th17) and its function in autoimmune diease
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摘要 辅助性T细胞分为调节性T细胞、Th1、Th2和Th17亚型。Th17细胞是新近发现的一个细胞亚群,其分泌的IL-17A和IL-17F是重要的致炎因子。本文综述了Th17分化和维持所需的微环境、Th17与其他主要免疫细胞的相互作用及Th17对自身免疫性疾病的影响,重点阐述了Th17相关的IL-23与Th1相关的IL-12之间的关系、树突状细胞对Th17分化的影响及Th17细胞对各种常见自身免疫性疾病的影响,通过对Th17细胞的深入研究将有助于认识自身免疫性疾病及进一步寻找新的治疗靶点。 CD4＋T helper cells（Th） were divided into regulatory T cells,Th1,Th2 and Th17 cells.Th17 cells were identified recently as a subtype of Th cells which mainly produce important pro-inflammatory cytokines,IL-17A and IL-17F.This paper reviewed the key cytokines for Th17 cells differentiation and maintenance,the interaction of Th17 cells with other immune cells and the role of Th17 cells in autoimmune diseases,and also dicussed the relation between IL-23 related to Th17 and IL-12 related to Th1,as well as the effect of dendritic cells on Th17 differentiation.Th17 cell is essential to many autoimmune diseases,so the study on it will help to understand the mechanism of these diseases,and further contribute to clinic therapy.
作者 唐冰 陈萍
机构地区 上海邮电医院麻醉科 复旦大学附属中山医院心内科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2012年第3期318-323,共6页 Fudan University Journal of Medical Sciences
关键词 辅助性T细胞17(Th17) 免疫细胞 自身免疫性疾病 T helper 17 cell（Th17） immune cell autoimmune disease
分类号 R392.12 [医药卫生—免疫学]
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参考文献57

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同被引文献44

  • 1Shen H, Goodall JC, Hill Gaston JS. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis[J]. Arthritis Rheum, 2009,60(6): 1647-1656.
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复旦学报（医学版）
2012年 第3期

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