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慢性疼痛中脊髓小胶质细胞激活机制的研究进展 被引量：3

Progress on the research of spinal cord microglia activation mechanism in chronic pain
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摘要 慢性疼痛中,神经元-脊髓小胶质细胞间的信号分子可以激活脊髓小胶质细胞,而激活的脊髓小胶质细胞可以释放多种与慢性疼痛有关的活性物质。实验研究表明,脊髓小胶质细胞表面受体的上调及细胞内激酶的激活在细胞的激活和慢性疼痛的发生和发展中起重要作用。 Many substances can activate microglia in the spinal cord,and activated microglia in the spinal cord can release a variety of active and pain-related substances.Experimental studies have shown that spinal cord microglia cell surface receptors and intracellular kinase activations play important roles in cell activation and chronic pain.
作者 肖凡 朱彪 廖庆武 罗振中
机构地区 南昌大学第二附属医院麻醉科 复旦大学附属中山医院麻醉科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2012年第3期324-326,330,共4页 Fudan University Journal of Medical Sciences
关键词 小胶质细胞 神经性疼痛 受体 丝裂原活化蛋白激酶(MAPKs) microglia neuropathic pain receptor mitogen-activated protein kinases（MAPKs）
分类号 R363 [医药卫生—病理学]
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参考文献18

  • 1Gosselin RD, Suter MR, Ji RR, et al. Glial cells and chronic pain [J]. The Neuroscientist, 2010, 16 (5) 519 - 531.
  • 2Watkins LR, Hutchinson MR, Ledeboer A, et al. Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids[J]. Brain Behav Immun,2007,21(2) :131 - 146.
  • 3Staniland AA, Clark AK, Wodarski R, et al. Reduced inflammatory and neuropathic pain and decreased spinal mieroglial response in fraetalkine receptor (CX3CR1) knockout mice [J]. J Neurochem, 2010, 114 (4): 1143 - 1157.
  • 4Zhuang ZY, Kawasaki Y, Tan PH, et al. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury induced cleavage of fractalkine[J]. Brain Behav Immun, 2007,21(5) :642 - 51.
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复旦学报（医学版）
2012年 第3期

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