西吡氯铵口含片治疗复发性阿弗他溃疡临床疗效评价

Clinical evaluation of cetylpyridinium chloride buccal tablets in treatment of recurrent aphthous ulcer

目的评价西吡氯铵口含片局部治疗复发性阿弗他溃疡(轻型)的疗效。方法本研究采用随机、阳性药物对照、单中心临床研究的方法,将74例复发性阿弗他溃疡患者分成试验组即西吡氯铵口含片组(37例),对照组即华素片组(37例),含化,疗程为7 d。分别于初诊时(第1天)、首次用药后第7天,记录溃疡疼痛指数、平均溃疡期、溃疡面积、受试者使用印象。数据采用EpiData 3.0软件输入,SAS 8.2软件分析。结果 2组患者治疗后溃疡面积和疼痛强度均较治疗前有显著改善,2组患者治疗后溃疡面积和疼痛强度之间无显著差异,但试验组溃疡愈合天数较对照组短(P<0.05)。结论西吡氯铵口含片治疗复发性阿弗他溃疡(轻型),能有效减轻溃疡造成的疼痛,促进溃疡快速愈合,无明显不良反应,且与对照组即华素片组比较,能明显缩短溃疡的愈合期。

Objective To investigate the efficacy of cetylpyridinium chloride buccal tablets in the treatment of recurrent aphthous ulcer（RAU,light）.Methods The study used the random masculine-medicine-comparison single-central clinical research method.74 patients with of recurrent aphthous ulcer were enrolled and randomly divided into two groups.37 patients were treated with cetylpyridinium chloride buccal tablets,while 37 patients were with cydiodine buccal tablets.Both tablets were taken perorally by the patients for 7 days.Ulcer pain index（UPI）,average ulcer stage（AUS）,ulcer area（UA） and impression of users were measured on day 1 and on day 8 respectively.Data were input with EpiData 3.0 software and analyzed with SAS 8.2.Results UPI and UA were significantly improved in both the experimental group and the control group（P0.05）.The difference in UPI and UA between the two groups was not significant（P0.05）.But ulcer healing time in the experimental group was shorter than control group（P0.05）.Conclusions Cetylpyridinium chloride buccal tablets can effectively reduce ulcer pain and shorten healing time of light recurrent ulcer.The clinical effects of cetylpyridinium chloride buccal in the treatment of light recurrent ulcer are equivalent to those of chloride buccal tablets.