溃疡性结肠炎患者外周血胎盘生长因子及VEGFR-1浓度检测及其意义分析

Serum PLGF and VEGFR-1 Level in Ulcerative Colitis

目的研究溃疡性结肠炎(UC)患者外周血胎盘生长因子(PLGF)及VEGFR-1水平,探讨PLGF及VEGFR-1在UC发病机制中的价值。方法采用ELISA法检测并比较40例UC患者及30例肠易激综合征(IBS)患者外周血PLGF及VEGFR-1水平的差异,并比较不同临床分期及不同病情外周血PLGF及VEGFR-1水平的差异。结果血清PLGF水平UC组(n=40)显著高于对照组(n=30)(35.32±3.66 vs 23.05±1.81pg/ml,P<0.001);活动组显著高于缓解组(36.34±3.21 vs 33.94±3.86pg/ml,P<0.05);轻(n=9)、中(n=9)、重度(n=5)组无显著差异(P>0.05);血清VEGFR-1水平UC组显著高于对照组(2.00±0.15 vs 1.05±0.11ng/ml,P<0.001);活动组显著高于缓解组(2.04±0.15 vs 1.94±0.12ng/ml,P<0.05);轻、中、重度组无显著差异(P>0.05)。结论 PLGF/VEGFR-1参与了炎症性肠病的发病机制,血管增生在UC的发病机制中具有复杂的病理生理意义。

Objective To evaluate serum PLGF and VEGFR - 1 level in ulcerative colitis（UC） and investigate the role of PLGF and VEGFR - 1 in the pathogenesis of UC. Methods We used enzyme - linked immune sorbent assays method to examine the serum level of PLGF and VEGFR - 1, and compare the difference between UC and control, and the difference between each disease course. Resuits Serum PLGF level increased significantly in UC than control（35.32 ± 3.66 vs 23.05 ±1.81 pg/ml, P 〈 0. 001 ）. It also increased more significantly in active group than in remission group （36.34 ± 3.21 vs 33.94 ±3.86pg/ml,P 〈 0.05 ）. No difference was found between each disease severity group. The level of serum VEGFR -1 increased significantly in UC than in control （2.00 ±0.15 vs 1.05 ± 0. 11 ng/ml,P 〈 O. 001 ） ; it also increased in active group than remission group （2.04 ± 0.15 vs 1.94± 0.12ng/ml,P 〈 0. 05 ）. No difference was found between each disease severity group. Conclusion PLGF/VEGFR - 1 system plays an important part in the pathogenesis of UC. and anzio enesis plays a comolicated role in UC.