益气清痹解毒汤联合依那西普对难治性强直性脊柱炎活动期患者血清TNF-α、IL-6的影响

Effects of Yiqi Qingbi Jiedu Decoction Combined with Etanercept on TNF-α and IL-6 in Patients with Refractory Spondylitis at Active Phase

目的:探讨益气清痹解毒汤联合依那西普对难治性强直性脊椎炎(AS)活动期患者肿瘤坏死因子(TNF-α)、白细胞介素(IL)-6的影响。方法:将76例难治性AS活动期患者随机分为治疗组(51例,益气清痹解毒汤联合注射用依那西普和对照组(25例,注射用依那西普),检测治疗3个月前后2组临床疗效和TNF-α、IL-6水平,并进行比较。结果:治疗组和对照组有效率分别为94.12%、64.00%,2组比较有显著性差异(P<0.05);治疗后治疗组较对照组TNF-α、IL-6含量下降更显著(P<0.05)。结论:益气清痹解毒汤联合依那西普能较快改善临床症状,明显抑制难治性AS活动期患者血清TNF-α、IL-6的表达。

OBJECTIVE ： To explore the effects of Yiqi qingbi jiedu decoction combined with etanercept on TNF-α and IL-6 in patients with refractory spondylitis at active phase. METHODS： 76 refractory spondylitis patients at active phase were randomly divided into treatment group （51 cases, Yiqi qingbi jiedu decoction and etanercept needle） and control group （29 cases, etanercept needle）. After 3 month of treatment, clinical efficacy and TNF-α and IL-6 level were observed and compared between 2 groups. RE- SULTS： The effective rates of treatment group and control group were 94.12% and 64.00%, there was statistical significance between 2 groups （P〈0.05） ; TNF-α and IL-6 levels of treatment group was more significantly than control group （P〈0.05）. CON- CLUSION： Yiqi qingbi jiedu decoction combined with etanercept can rapidly improve the clinical symptoms, and inhibit the expression of TNF-α and IL-6 in refractory spondylitis patients at active phase significantly.