1778例母婴梅毒血清学分析

Serological analysis on 1778 pregnant women and neonates with syphilis

目的:为深圳市预防与控制梅毒母婴传播项目提供新的临床依据。方法:对深圳市宝安区各个医院送检标本同时进行甲苯胺红不加热血清试验(TRUST)和梅毒螺旋体颗粒凝集试验(TPPA)。结果:从2008年1月1日～2009年12月31日共收集孕妇和新生儿血清标本1 778份,其中孕妇TRUST和TPPA的血清阳性率分别为89.32%(920/1 030)和79.80%(822/1 030),新生儿TRUST和TPPA的血清阳性率分别为50.00%(374/748)和60.56%(453/748);新生儿TRUST滴度大于1∶8(包括1∶8)者为3.07%,明显低于孕妇的20.10%。另外,2009年全年的真阳性率低于2008年。结论:母婴梅毒控制工作有效地控制了梅毒的母婴垂直传播,需进一步在孕早期加大对梅毒的筛查力度。

Objective： To provide a new basis for preventing and controlling project of maternal - infantile transmission of syphilis in Shenzhen city. Methods： The examined specimens from each hospital in Baoan district underwent toluidine red unheated serum test （TRUST） and treponema pallidum particle agglutination （TPPA） test simultaneously. Results： A total of 1 778 serum specimens of pregnant women and neonates were collected from January 1 st, 2008 to December 31 st, 2009. The positive rates of maternal serum specimens detected by TRUST and TPPA were 89.32% （920/1 030） and 79.80% （822/1 030）, respectively. The positive rates of neonatal serum specimens detected by TRUST and TPPA were 50. 00% （374/748） and 60. 56% （453/748）, respectively ; TRUST titer of 3.07% of the neonates was more than 1：8 （including 1： 8） ; which was significantly lower than the percentage of pregnant women （20. 10% ） . The true positive rate in 2009 was lower than that in 2008. Conclusion ： Control work of syphilis among pregnant women and neonates can control maternal - infantile transmission of syphilis effectively, the screening of syphilis during the first trimester of pregnancy should be further enhanced.