子宫内膜癌患者PTEN的表达及其临床意义探讨

Discussion of the expression and significance of PTEN in the patients with endometrial cancer

目的:研究抑癌基因PTEN在子宫内膜腺癌组织中的表达及其与预后的关系。方法:采用免疫组化SP法检测103例子宫内膜腺癌病理标本PTEN的表达,并对其中54例患者进行5年随访,对PTEN表达情况与生存率进行相关性分析。结果:①子宫内膜腺癌患者PTEN阳性表达率明显高于健康对照组(χ2=83.96,P<0.001)。②子宫内膜腺癌组织分级G3级、临床分期Ⅲ-Ⅳ期、浸润超过1/2肌层厚度及有淋巴结转移者PTEN阳性表达明显降低。③PTEN阳性率与子宫内膜癌术后5年存活率有关(χ2=7.64,r=0.3521,P<0.01),PTEN高表达者,术后5年存活率也越高。结论:子宫内膜癌患者存在PTEN表达下调,PTEN表达与子宫内膜癌临床病理分级、分期、癌细胞浸润、转移及预后有关;子宫内膜组织PTEN检测对诊断子宫内膜癌并判定其恶性程度和预后具有重要意义。

Objective： To study the expression of tumor suppressor gene -PTEN in endometrial adenocarcinoma and its relationship with the prognosis. Methods ： Immunohistochemical SP method was used to detect the expression of PTEN in 103 specimens of endometrial adenocarcinoma, and 54 patients were followed up for five years, the con＇elation between the expression of PTEN and survival rate was analyzed. Results： The positive expression rate of PTEN in endometrial adenocarcinoma group was significantly higher than that in health control group （X^2 = 83.96, P 〈 0. 001 ） . In endometrial adenoeareinoma group, the positive expression rate of PTEN among the patients with G3 grade, stage Ⅲ- Ⅳ, the depth of invasion more than 1/2 of myometrium, and lymph node metastasis decreased significantly. There was correlation between the positive rate of PTEN and five - year survival rate （X2 =-7.64, Y = 0. 3521, P 〈 0. 01 ）, the higher the positive rate of PTEN was, the higher five - year survival rate was. Conclusion： Down - regulation of PTEN exists in the patients with endometrial adenocarcinoma, PTEN expression is correlated with clinicopathological grades, clinical stages, invasion, metastasis, and prognosis of endo- metrial adenocarcinoma; PTEN detection plays an important role in diagnosing endometrial adenocarcinoma and determining malignant degree and prognosis.