摘要
癫是多种原因引起大脑局部神经元异常高频放电所致的大脑功能失调综合征。脑部异常放电可能因脑内兴奋及抑制系统失平衡而产生。研究认为,癫发病机制与离子通道、神经递质功能、神经胶质细胞等密切相关。由于癫发病机制不同,抗癫药物的作用机制也不尽相同。本文综述抗癫药的作用机制,进一步研究癫的发病机制。
Epilepsy is a brain dysfunction syndrome caused by local brain neurons abnormal discharge.Abnormal discharge in the brain may be produced by unbalance of cerebral excitatory and inhibitory system.The studies suggested that the pathogenesis of epilepsy be closely related to ion channels,neurotransmitter,and neurogliocytes.With different pathogenesis of epilepsy,the mechanism of anti-epileptic drugs varies.The mechanism of anti-epileptic drugs,and further reflection on the pathogenesis of epilepsy were reviewed.
出处
《中国临床神经科学》
2012年第3期350-354,共5页
Chinese Journal of Clinical Neurosciences
基金
山东省自然基金项目(编号:ZR2011HL008)
山东省卫生厅课题(编号:2011HD017)
关键词
癫
抗癫药
发病机制
epilepsy
anti-epileptic drug
pathogenesis
