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灰区淋巴瘤的病理认识与临床治疗观察 被引量：5

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摘要 目的探讨灰区淋巴瘤(GZL)具有的病理形态、免疫表型及临床表现形式。方法总结收治的GZL确诊病例4例,并对其病理形态、免疫组化表型及临床治疗转归进行回顾。结果 4例患者经过治疗,完全缓解(CR)2例,疾病未控最终死亡2例,目前2例CR病例仍存活,其中1例已随访30个月。结论 GZL较霍奇金淋巴瘤或弥漫大B细胞淋巴瘤更具侵袭性临床病程,预后较差。治疗过程中接受较为温和而经典的方案如CHOP(环膦酰胺+阿霉素+长春新碱+泼尼松)、ABVD(阿霉素+博来霉素+长春花碱酰胺+氮烯咪胺)、R-CHOP(利妥昔单抗+环膦酰胺+阿霉素+长春新碱+泼尼松)、DICE(顺铂+异环膦酰胺+足叶乙甙+地塞米松)等方案均没有出现预期效果,而更换BEACOPP(博来霉素+足叶乙甙+阿霉素+环膦酰胺+长春新碱+甲基卞肼+泼尼松)或自体外周血干细胞移植方案治疗或再同步给予化放疗控制效果有所提高。
作者 苏航 达永 肖秀彬 仲凯励 张伟京
机构地区 解放军
出处 《中国医刊》 CAS 2012年第5期62-64,共3页 Chinese Journal of Medicine
关键词 灰区淋巴瘤 病理 治疗
分类号 R733 [医药卫生—肿瘤]
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参考文献7

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二级参考文献56

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共引文献14

同被引文献59

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引证文献5

二级引证文献8

中国医刊
2012年 第5期

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