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骨生长因子NELL-1的研究进展 被引量：3

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摘要 Nel样分子I型(Nel-like type I molecular,NELL-1)是一种与人颅缝早闭症相关的外分泌型蛋白,近年来一系列体外及体内研究表明NELL-1更是一种非常有效的骨生长因子。与其他骨生长因子相比,NELL-1的生物学效应相对单一,其骨诱导活性也更具有特异性,同时它无法单独诱导异位骨组织形成,因此NELL-1可具有更高的生物安全性和精准性。NELL-1作为一种全新的生长因子在治疗各类骨组织缺损与骨再生方面具有广阔而良好的应用前景。本文就目前NELL-1在骨再生领域的应用及其作用机制研究的进展做一综述。
作者 刘亚京 陈彩云 刘洪臣
机构地区 解放军总医院口腔医学研究所 解放军军医进修学院
出处 《口腔颌面修复学杂志》 2012年第1期52-56,共5页 Chinese Journal of Prosthodontics
关键词 Nel样分子I型 骨 组织工程
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献41

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二级参考文献34

共引文献12

同被引文献43

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口腔颌面修复学杂志
2012年 第1期

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