利培酮与氯氮平治疗老年期女性精神分裂症的60例对照研究

Risperidone and Clozapine in the treatment of senile female schizophrenia 60 cases control study

目的:比较利培酮与氯氮平治疗老年期女性精神分裂症的临床疗效和安全性。方法:将60例老年期女性精神分裂症患者,随机分为利培酮组与氯氮平组,治疗8周,以阳性和阴性症状量表(PANSS)评定临床疗效,以不良反应量表(TESS)和实验室监测评定其安全性。结果:PANSS量表总分、TESS量表和实验室监测均有显著性差异(P<0.05)。结论:利培酮对老年期女性精神分裂症患者疗效好,安全性高。

Objective：To compare of Risperidone and Clozapine in the treatment of senile female schizophrenia clinical efficacy and safety.Methods：60 cases of senile female patients with schizophrenia were randomly divided into groups,Risperidone and Clozapine group,treatment of 8 weeks,with the positive and negative symptoms scale（PANSS） assessment of clinical efficacy,adverse reactions to scale（TESS） and laboratory monitoring evaluation of its safety.Results： The PANSS total score,TESS and laboratory monitoring there were significant differences＇ 0.05.Conclusions： Risperidone in senile female patients with schizophrenia has good curative effect,high safety.