全基因组关联研究在高血压研究中的应用

Application of GWAS in the Essential Hypertension Study

原发性高血压是一种常见的复杂性疾病,其发病受到多个微效基因和环境因素的共同作用。全基因组关联研究(GWAS)是一种在全基因组范围内对高密度遗传标记进行分型,并找出与疾病相关的遗传因素的关联研究方法。本文介绍了GWAS的原理及其在原发性高血压研究中的优势;回顾了GWAS在原发性高血压研究中的主要发现;并对运用GWAS在原发性高血压研究中尚需解决的问题进行了总结和展望。

Essential Hypertension （EH） is a common complex disease,resulting from the interaction between some minor genes and environmental factors.As a new type of population-based association study,genome-wide association study（GWAS） can be used to deteet sequence variations related to diseases in the range of whole genome.The principle Of GWAS,advantages of GWAS in the studies of EH,and primary findings of GWAS on EH are reviewed.This paper also summarized the shortcomings of current GWAS on EH and perspectives of its future.