佩戴镍铬烤瓷冠对肾功能的影响

The impact on renal function by dental restoration of nickel-chromium alloys

目的探讨镍铬合金烤瓷冠的佩戴是否会造成机体肾功能的损伤。方法对33例镍铬合金烤瓷冠佩戴者进行佩戴前和佩戴2月后的肾功能重复测量,并采用配对t检验和重复测量数据线性回归分析探讨肾功能的变化与镍铬合金冠佩戴的关系。结果配对t检验未观察到镍铬合金烤瓷冠的佩戴对各血尿肾功能生化指标(血:总蛋白、白蛋白、血肌酐、血尿素氮、血尿酸、肾小球滤过率的估计值;尿:白蛋白、N-乙酰-β-D-氨基葡糖苷酶、视黄醇结合蛋白、β2-微球蛋白)实测值和异常率的明显改变。重复测量数据的广义线性模型仅发现年龄和肾功能的异常有关,但与镍铬合金烤瓷冠的佩戴时间、数量和金属裸露水平无关。结论镍铬合金烤瓷冠的佩戴与机体的肾功能损伤无明确相关性。

Objective To explore whether the dental restoration of nickel-chromium（Ni-Cr） will lead to renal dysfunction.Methods A prospective follow-up study was conducted in 33 patients undergoing dental restoration of Ni-Cr alloy,and the associations of alloy restoration with biological parameters of renal function were analyzed by paired t test and general linear model of repeated measures.Results Paired t test did not show any significant change in both of the measurement values and the prevalence of abnormal serum or urine parameters of renal function（Serum： total protein,albumin,urea nitrogen,urea acid and estimated glomerular filtration rate（eGFR）;urine： albumin,N-acetyl-β-D-glucosaminidase,retinol-binding protein and β2-microglobulin）（P0.05）.General linear models of repeated measures of renal dysfunction only showed a positive association with age,but with the time and number of alloy restoration,and the level of metal basis uncovered with porcelain.Conclusion Dental restoration of Ni-Cr alloy might not lead to the renal dysfunction in this prospective follow-up study.