献血者感染HBV相关危险行为因素的调查研究

The risk behavior factors for hepatitis B infection in blood donors

目的研究献血者感染乙肝病毒(HBV)的相关危险因素。方法对203名单纯HBsAg阳性的献血者及406名所有血液检测项目均阴性的献血者进行对照研究,应用多因素条件Logistic回归模型分析与HBV感染有关的因素,并对危险因素的人群归因危险度(PAR)进行估计。结果筛选出5项与感染HBV有关的因素,研究发现使用共用剃刀、乙肝家族史、内窥镜检查史、牙科治疗史、未注射乙肝疫苗可以增加乙肝感染的危险性,其危险度(OR)分别是:4.010 2、2.808 2、5.815 7、1.758 3、4.044 4,人群归因危险度分别是:43.39%,5.50%,1.75%,13.46%,29.91%。5项危险因素总的人群归因危险度为66.78%。结论使用共用剃刀、乙肝家族史、内窥镜检查史、牙科治疗史、未注射乙肝疫苗是HBV感染的危险因素。

Objective To research the risk behavior factors for hepatitis B infection in blood donors. Methods 203 blood donors with positive ELISA results for HBsAg were cases, and 406 controls tested negative. A standardized questionnaire was used to collect data concerning demographic aspects and potential risk factors. Cases and controls were compared using logistic regression to calculate crude and adjusted odds ratios, and 95% confidence intervals for risk factors. Results According to the multiple condition Logistic regression model, shared razors, hepatitis B family history, endoscopy history , dental treatment history and no injected hepatitis B vaccine can increased the risk of HBV infection, the OR value for these items is 4. 010 2、2. 808 2、5. 815 7、1. 758 3、4. 044 4. Respectively,PAR for each of them is 43.39% ,5.50%, 1.75%, 13.46% ,29.91% ,the total PAR is 66. 78%. Conclusion Shared razors, hepatitis B family history, endoscopy history, dental treatment history and no injected hepatitis B vaccine are risk factors for hepatitis B infection.