摘要
In the cell nucleus,DNA is wound around histone proteins,which are then packed together to form chromatin.Histones can be chemically tagged by methyl and acetyl groups.Polycomb group (PcG) proteins attach methyl groups to genes,which block their activity.This is similar to the attachment of methyl groups to gene promoters by DNA methyltransferases (DNMTs).This action is directly linked with tumor initiation and metastasis via the promotion of anti-senescence and anti-apoptosis pathways,and by facilitating epithelial mesenchymal transition (EMT).Cell fate transcriptional factors (CFTFs) and long non-coding RNAs (long ncRNAs) recruit PcG proteins to the promoters of tumor suppressor genes,resulting in epigenetic gene silencing by influencing chromatin structure and DNA accessibility.Thus,PcG proteins are potential diagnostic markers and targets for new chemoprevention and therapeutic strategies.
In the cell nucleus, DNA is wound around histone proteins, which are then packed together to form chromatin. Histories can be chemically tagged by methyl and acetyl groups. Polycomb group （PEG） proteins attach methyl groups to genes, which block their activity. This is similar to the attachment of methyl groups to gene promoters by DNA methyltransferases （DNMTs）. This action is directly linked with tumor initiation and metastasis via the promotion of anti-senescence and anti-apoptosis pathways, and by facilitating epithelial mesenchymal transition （EMT）. Cell fate transcriptional factors （CFTFs） and long non-coding RNAs （long ncRNAs） recruit PeG proteins to the promoters of tumor suppressor genes, resulting in epigenetic gene silencing by influencing chromatin structure and DNA accessibility. Thus, PeG proteins are potential diagnostic markers and targets for new chemopre- vention and therapeutic strategies.
作者
XIAO LanBo 1,2,3,TAO YongGuang 1,2,3,LI LiLi 1,2,3,4 & CAO Ya 1,2,31 Key Laboratory of Carcinogenesis of Ministry of Health,Xiangya School of Medicine,Central South University,Changsha 410078,China
2 Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Xiangya School of Medicine,Central South University,Changsha 410078,China
3 Cancer Research Institute,Xiangya School of Medicine,Central South University,Changsha 410078,China
4 Cancer Epigenetics Laboratory,State Key Laboratory in Oncology in South China,Chinese University of Hong Kong,Hong Kong 999077,China
基金
supported by the National Basic Research Program of China(2011CB504300)
the National Natural Science Foundation of China(30930101)
