不同剂量的阿托伐他汀对多社区颈动脉硬化斑块人群颈动脉硬化斑块的消退作用临床观察被引量：1

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摘要目的:采用颈动脉超声观察不同剂量阿托伐他汀治疗对颈动脉硬化斑块患者的疗效和安全性。方法:对多个社区人群常规行颈部彩超检查,选择有颈动脉硬化斑块的病例300例.分为低剂量组(阿托伐他汀10mg/d)和高剂量组(阿托伐他汀40mg/d),共服药6个月。观察用药前、治疗后6个月时颈动脉内-中膜厚度(IMT)变化情况及药物的副作用。结果:2组患者一般临床情况及各种生化指标在治疗前差异无显著性。与治疗前比较,阿托伐他汀40mg/d治疗6个月后。均呈显著性下降(P<0.05);阿托伐他汀10mg/d治疗6个月后,IMT下降均无显著性。2组之间比较,40mg/d阿托伐他汀较10mg/d更能显著性降低IMT(P<0.05),高剂量组中有3例患者于4个月时出现肝脏转氨酶轻度增高,复查后达到正常。结论:10mg/d的阿托伐他汀的治疗强度是不够的;而长期服用40mg/d的阿托伐他汀,可以在安全及有效基础上,稳定并消退颈动脉硬化斑块。

作者周典贵惠凯李春双杨巍郭柳彩蔡振丽

机构地区大庆油田总医院集团龙南医院齐齐哈尔医学院第五附属医院神经内科

出处《中国伤残医学》 2012年第5期77-79,共3页 Chinese Journal of Trauma and Disability Medicine

关键词颈动脉硬化斑块颈动脉血管内-中层厚度动脉斑块消退副作用

分类号 R91 [医药卫生—药学]

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