AFP联合AFP-L3、ALP和AFU检测在原发性肝癌诊断中的价值

Diagnostic value of combined detection of AFP,AFP-L3,ALP and AFU levels in primary liver cancer

目的:探讨甲胎蛋白联合AFP-L3、ALP和AFU检测对原发性肝癌的诊断价值。方法:使用化学发光法分别检测原发性肝癌患者(142例)、肝硬化患者(106例)和正常对照组(125例)AFP、AFP-L3、ALP和AFU的血清含量,分析这些肿瘤标记物对原发性肝癌诊断的阳性率。结果:原发性肝癌组AFP、AFP-L3、ALP、AFU的阳性率分别为74.6%、73.9%、42.2%、76.3%,与肝硬化组相比较,差异有统计学意义(P<0.01)。四项检测指标联合对原发性肝癌诊断的阳性率为98.6%,与单项检测指标相比差异有统计学意义(P<0.01)。结论:AFP、AFP-L3、ALP和AFU对原发性肝癌的诊断有一定的临床应用价值,联合检测可提其诊断率。

Objective：To investigate the diagnostic value of combined detection of AFP, AFP-L3, ALP and AFU levels in primary liver cancer. Methods： Serum levels ofAFP, AFP-L3, ALP and AFU were measured in 142 patients with primary liver cancer, 106 patients with liver cirrhosis group and 125 healthy subjects by chemiluminescence method in which the positive rate of diagnosing primary liver cancer was analyzed. Results： Positive rate of AFP, AFP-L3, ALP and AFU in primary .hepatic cancer was respectively 74.6%, 73.9%, 42.2% and 76.3% in which the difference was statistically significant （P〈0.O1） comparing with liver cirrhosis group and healthy subjects group. The positive rate of those four serum markers was 98.6% in which the difference was statistically significant（P〈0.01 ） comparing with single examination marker. Conclusion： AFP, AFP-L3, ALP and AFU have certain diagnostic value for primary liver cancer in which united detection can raise the diagnosis rate of primary liver cancer.