1-芳酰基-4-(1'-N-β-D-吡喃型糖基)氨基硫脲类化合物的合成(英文)

Stereoselective Synthesis of 1-[1'-Aroyl thiosemicarbazide-4'-YL)-N-β-D-glycopyranosides

通过 2 ,3,4 ,6 四 O 乙酰基 β D 吡喃型葡萄糖异硫氰酸酯和 2 ,3,4 三 O 乙酰基 β D 吡喃型木糖异硫氰酸酯与取代的芳基酰肼的亲核加成反应合成了 1 0个 1 芳酰基 4 ( 1′ N 2′,3′,4′,6′ 四 O 乙酰基 β D 吡喃型葡萄糖基 )氨基硫脲和 7个 1 芳酰基 4 ( 1′ N 2′,3′,4′ 三 O 乙酰基 β D 吡喃型木糖基 )氨基硫脲 ,所得化合物的结构经元素分析 ,IR ,1 HNMR确证 .

The synthesis of some new 1 aroyl 4 [1′ N 2′,3′,4′,6′ tetra O acetyl β D glucopyranosyl and 1′ N 2′,3′,4′ tri O acetyl β D xylopyranosyl] thiosemicarbazides by condensation of 2,3,4,6 tetra O acetyl β D glucopyranosyl isothiocyanate and 2,3,4 tri O acetyl β D xylopyranosyl isothiocyanate with aroyl hydrazines in 95% EtOH under reflux was reported, and their structures were confirmed by elemental and spectral analysis.