α-氧代烯酮环二硫代缩酮化学——α-氧代烯酮环二硫代缩酮与烯丙基Grignard试剂加成物的甲醚化反应

Oxoketene Cyclic Dithioacetal Chemistry——The Etherifying Reaction on the Adducts of Aliphatic α-Oxoketene Cyclic Dithioacetals with Allyl Magnesium Bromide

在BF3 ·Et2 O催化下 ,脂肪族α 氧代烯酮环二硫代缩酮与烯丙基Grignard试剂 1 ,2 加成物 ,同亲核试剂甲醇反应得甲醚化物 ,产物经元素分析、IR ,1HNMR确证。

Aliphatic α oxoketene cyclic dithioacetals(1) were reacted with allyl magnesium bromide to afford the 1,2 addition products 2. The adducts 2 were etherified by methanol to afford the corresponding methyl ethers 3 in the presence of boron trifluoride etherate as a catalyst. This process provides a new method for the protection of the acid sensitive hydroxyl troup in 2 under mild condition.