氟康唑与制霉菌素联合碳酸氢钠治疗小儿鹅口疮44例临床疗效比较

Clinical Curative Effect Comparison of Fluconazole Versus Nystatin Combined with Sodium Bicarbonate in the Treatment of 44 Cases Pediatric Thrush

目的:观察氟康唑与制霉菌素联合碳酸氢钠注射液治疗小儿鹅口疮临床疗效比较,为临床治疗鹅口疮用药选择提供指导。方法:将88例鹅口疮患者随机分为两组,氟康唑组采用氟康唑胶囊(5mg/kg.d,每日1次,午餐后服),制霉菌素组采用制霉菌素联合碳酸氢钠注射液(2.5%碳酸氢钠溶口腔护理后,制霉菌素研粉口腔内涂沫),5d后比较两组的效果,口腔体征改善的情况。结果:氟康唑组治疗总有效率88.63%,制霉菌素组治疗总有效率84.09%,统计学分析显示两组疗效无显著差异。(P>0.05)。结论:氟康唑与制霉菌素联合碳酸氢钠注射液治疗鹅口疮疗效相近,可以根据病人经济状况、不良反应、病人耐药性、舒适性等具体情况选择用药。

Objective： To observe clinical curative effect the fluconazole versus nystatin combine with sodium bicarbonate injection in treatment of infant thrush,for clinical treatment of thrush drug selection guide. Method： 88 cases of thrush were randomly divided into two groups,fluconazole group using fluconazole capsule（5mg / kg.d,once a day,after lunch,clothing）,nystatin nystatin group combined with sodium bicarbonate injection（2.5% sodium bicarbonate solution of oral care,oral nystatin levigation smear）,5 days later comparison of two group effect,oral signs to improve the situation. Result： Total effective rate was fluconazole treatment group 88.63%,total effective rate was 84.09% in nystatin treatment group,statistical analysis showed no significant differences between the two groups.（P 0.05）. Conclusion： Fluconazole versus nystatin combined with sodium bicarbonate injection in the treatment of oral thrush similar results,according to the patients economic conditions,adverse reactions,drug resistance,comfort and other specific circumstances to choose medicine.