稀土杂多配合物的合成、表征及其稳定性、弛豫性质

Synthesis, Characterization,Stability and Relaxation Behaviours of Rare Earth Heteropolymetalates

以N_9GdW_(10)O_(36)和K_(11)[Gd(PW_(11)O_(39)_2]作为研究对象,根据元素分析,红外光谱及差热-热重分析进行表征,对两种稀土杂多配合物的稳定性、溶解性进行了研究,并测试了其在水中及BSA溶液中的弛豫性能.其弛豫效率略高于目前临床所用的造影剂Gd-DTPA结果表明。

Two rare earth heteropolymetalates K9GdW10O36 and K11 [Gd(PW11O39)2] have been synthesized and characterized by IR and elemental analysis. Their stability has been studied by TG - DTA. The TG - DTA analysis show that both complexes are of good thermal stability. Their relaxivity in D2O is 6. 89 and 5. 27 mmol-1·L·s-1 respectively. Interaction with BSA has also been investigated. The results indicate that the two rare earth heteropolymetalate may be potential contrast agent for MRI.