摘要
甲状腺相关眼病是一种器官特异性自身免疫性疾病,其具体发病机制尚不完全清楚。目前,多数学者倾向于该病是抗甲状腺和眼的抗原的交叉免疫反应,甲状腺功能亢进和眼病是同一疾病累及两个不同的特异器官。近年来甲状腺相关眼病相关自身抗原(包括促甲状腺素受体、眼肌膜抗原、G2S、黄素蛋白、α-胞衬蛋白、葡萄膜自身抗原和肌集钙蛋白等相关抗原)及对应抗体的研究为甲状腺相关眼病活动性的客观评价提供了广阔的前景,现对此作一综述。
Thyroid-associated ophthalmopathy（TAO）is an organ specific autoimmune disease,the pathogenesis of which is not very clear up to now.At present,most scholars tend to believe that TAO is caused by immune cross-reactivity between orbital and thyroid antigens.Hyperthyroidism and ophthalmopathy are two target organs′ manifestations involved in one disease.In recent years,the researches of TAO related autoantigen（including thyroid-stimulating hormone receptor,eye muscle membrane antigen,G2S,flavin protein,fodrin,uveal autoantigen protein,and troponin related antigen etc.）and corresponding antibodieshave given extensive prospect in TAO,which are to be reviewed here.
出处
《医学综述》
2012年第9期1374-1376,共3页
Medical Recapitulate
关键词
甲状腺相关眼病
自身抗原
自身免疫
Thyroid-associated ophthalmopathy
Autoantigen
Autoimmunity
