摘要
核因子κB(NF-κB)是一种广泛存在并具有广泛生物学活性的核转录因子,其调控的靶基因包括细胞因子、趋化因子、转录因子、氧化应激相关酶及急性期蛋白等,进而参与调控炎症和免疫反应、细胞生长发育、细胞凋亡及应激反应等多种生物过程。研究发现在糖尿病肾病(DN)的局部肾组织中存在过度激活的NF-κB,其过度激活与肾小球系膜细胞增生和分泌炎性因子密切相关。因此,深入研究NF-κB与DN的关系,有助于DN的临床防治。
Nuclear factor-κB（NF-κB）is a transcription factor widely distributed in most cell types with extensive biologic activity,which regulates the expression of numerous genes such as cytokine,chemotactic factor,transcriptionfactor,oxidative stress related enzymes,and acute-phase proteins etc.,accordingly participating in many bioprocesses such as inflammation responses,immunoreaction,apoptosis and stress reaction etc..It has been found that excessive activation of NF-κB which exists in local nephridial tissue of diabetic nephropathy（DN）has a closely relationship with the proliferation of mesangial cell and the secretion of inflammatory factors.Therefore,deeper study of the relationship between NF-κB and DN contributes to the clinical prevention and therapy.
出处
《医学综述》
2012年第9期1388-1391,共4页
Medical Recapitulate
关键词
核因子ΚB
糖尿病
糖尿病肾病
Nuclear factor-κB
Diabetic mellitus
Diabetic nephropathy
