深圳市流动人口与户籍居民乙肝感染情况比较分析

Comparisons and analysis of the hepatitis B infection status of transient population and registered residents in Shenzhen City

目的通过对深圳流动人口与户籍居民乙型肝炎(以下简称乙肝)血清标志物的检测,了解深圳市居民乙肝感染情况及其差异性,为控制乙肝传播提供科学依据。方法采用多阶段整群抽样方法,于2010年7～8月抽取深圳流动人口和户籍居民3 771人(流动人口1 873人,本地户籍居民1 898人),进行问卷调查同时采集血样,用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测血清中乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs)和乙肝核心抗体(抗-HBc)。结果深圳市流动人口HBsAg阳性率为7.05%,略高于户籍居民(6.32%);抗-HBs阳性率为67.16%,低于户籍居民(76.61%);深圳市流动人口与户籍居民HBsAg阳性率在各年龄组间差异无统计学意义(X2=0.79,P=0.373);深圳流动人口中低文化水平人群(初中及以下)HBsAg阳性率高于高文化水平人群(高中及以上)(X2=7.01,P=0.008);出生在深圳的流动人口HBsAg阳性率远低于出生地在其他省市的流动人口。结论深圳流动人口乙肝感染情况比深圳户籍居民严重,因此加强深圳流动人口常规免疫和查漏补种工作对控制深圳乙肝流行十分重要。

Objective To understand the hepatitis B infection status and differences of registered residents and transient population by detecting hepatitis B serum biomarkers in their blood.Methods With multi-stage cluster random sampling method,1 898 registered residents and 1 873 transient population were recruited in July and August,2010.Blood samples were collected after questionnaires.Hepatitis B virus surface antigen（HBsAg）,hepatitis B virus surface antibody（anti-HBs） and hepatitis B virus core antibody（anti-HBc） were detected with enzyme-linked immunosorbent assay（ELISA）.Results The positive rate of HBsAg in transient population was 7.05%,which was slightly higher than registered residents（6.32%）;The positive rate of anti-HBs of transient population was 67.16%,which was lower than registered residents（76.61%）.The positive rate of HBsAg in all age groups both in tansient population and registered residents had no significant difference（Х^2=0.79,P=0.373）.Positive rate of HBsAg was much higher for people with low educated levels than that with high educated levels in transient population（Х^2=7.01,P=0.008）.Transient population who were born in Shenzhen have lower HBsAg positive rate than those born in other provinces and cities.Conclusions The infection of hepatitis B virus of transient population is much more severe than registered residents in Shenzhen,thus it is of highly importance to strengthen normal immune and leakage searching reseed work in transient population for controlling the spread of hepatitis B virus in Shenzhen City.