摘要
3-氨基-6-氯哒嗪是合成第四代头孢类抗生素—头孢唑兰的重要中间体。本文以马来酸酐为起始原料,通过肼解、卤代以及微波辅助氨解法合成了3-氨基-6-氯哒嗪,优化了反应条件,探讨了影响反应的主要因素,反应收率理想,微波辅助合成取得了较好的效果。用1H NMR对各步产品进行了表征。
3 - amino - 6 - chloro pyridazine was an important intermediate of the fourth - generation cephalosporins : cefozopran. Maleic anhydride as the starting material, 3 - amino - 6 - chloro - pyridazine was synthesized through hydrazinolysis, halogenated reaction and microwave- assisted ammonolysis. The reaction conditions were optimized, the main factors affecting the reaction were discussed, the yield was good and the microwave - assisted reaction worked out well. 1H NMR spectrum was used to identify the product from each step.
出处
《广州化工》
CAS
2012年第9期121-122,共2页
GuangZhou Chemical Industry
关键词
马来酸酐
3-氨基-6-氯哒嗪
头孢唑兰
微波合成
maleic hydrazide
3 - amino - 6 - ehloro - pyridazine
cefozopran
microwave synthesis