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3-氨基-6-氯哒嗪的微波合成研究

Study on Microwave Synthesis of 3-Amino-6-Chloro-Pyridazine
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摘要 3-氨基-6-氯哒嗪是合成第四代头孢类抗生素—头孢唑兰的重要中间体。本文以马来酸酐为起始原料,通过肼解、卤代以及微波辅助氨解法合成了3-氨基-6-氯哒嗪,优化了反应条件,探讨了影响反应的主要因素,反应收率理想,微波辅助合成取得了较好的效果。用1H NMR对各步产品进行了表征。 3 - amino - 6 - chloro pyridazine was an important intermediate of the fourth - generation cephalosporins : cefozopran. Maleic anhydride as the starting material, 3 - amino - 6 - chloro - pyridazine was synthesized through hydrazinolysis, halogenated reaction and microwave- assisted ammonolysis. The reaction conditions were optimized, the main factors affecting the reaction were discussed, the yield was good and the microwave - assisted reaction worked out well. 1H NMR spectrum was used to identify the product from each step.
出处 《广州化工》 CAS 2012年第9期121-122,共2页 GuangZhou Chemical Industry
关键词 马来酸酐 3-氨基-6-氯哒嗪 头孢唑兰 微波合成 maleic hydrazide 3 - amino - 6 - ehloro - pyridazine cefozopran microwave synthesis
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参考文献10

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