血清同型半胱氨酸检测水平与冠心病临床相关性的探讨

目的探讨血清同型半胱氨酸（HCY）检测水平与冠心病（CHD）的临床相关性。方法选择经冠状动脉造影检查确诊为冠心病的门诊及住院患者98例，并选择同期体检的健康人90例，比较两组血清HcyZk平；将CHD患者按心功能分级、冠状动脉狭窄程度及病变支数分别分组，观察不同分组与血清Hcy水平的临床相关性。结果CHD组患者血清HCY水平与HHCY检出率均显著高于健康人群（P〈0．01）；血清HCY水平与患者心功能分级、病变严重程度和病变支数具有正相关性（P〈0．05），随着严重程度的增加，血清HCY水平随之增加（P〈0．05）。结论血清HCY水平与CHD的发生发展密切相关，对血清HCY水平的检查可指导临床对CHD的治疗与保健。

Objective To research the clinical correlation of serum homocysteine level with coronary heart disease. Method Collecting 98 CHD patients inspected by coronary angiography and 90 healthy people as control, to compare the level of serum Hey and observe the clinical correlation of serum homocysteine level with functional class, coronary artery stenosis and number of diseased vessels. Result The CHD group＇s serum homoeysteine level was higher than the healthy people （ P 〈0.01 ） , the serum homocysteine level was negatively correlated with functional class, coronary artery stenosis and number of diseased vessels （ P〈0.05 ） . Conclusion The serum homocysteine level is closely related to the CHD, it could guide clinical treatment and health care by inspecting the serum HCY level.