枯草杆菌二联活菌颗粒在儿童腹型过敏性紫癜中的应用

Application of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines-Live in Treatment of Henoch Purpura in Children

目的:观察枯草杆菌二联活菌颗粒在儿童腹型过敏性紫癜(HSP)治疗中的辅助作用。方法:将139例腹型HSP住院患儿中完成研究的125例纳入研究对象,采用随机数字表法随机分为观察组70例和对照组55例。对照组给予西咪替丁、维生素C、钙剂及糖皮质激素等综合治疗,合并感染者给予抗生素治疗,观察组在对照组治疗基础上加服枯草杆菌二联活菌颗粒,年龄4～6岁,1 g/次,～12岁,1.5 g/次,均为3次/d,7 d为1个疗程。观察两组患儿消化道症状(腹痛、呕吐、便血等)的变化、治疗1周后唾液分泌型IgA(sIgA)含量的变化及1周后的临床疗效。结果:观察组消化道症状消失时间均短于对照组(P<0.01)。1周后,观察组sIgA与治疗前比较显著升高(t=4.556,P<0.01),而对照组与治疗前比较差异无统计学意义(t=0.914,P>0.05),总有效率观察组95.71%,对照组81.82%,两组比较差异有统计学意义(χ2=4.978,P<0.05)。结论:枯草杆菌二联活菌颗粒可提高消化道粘膜的免疫功能,佐治儿童腹型HSP,可较快缓解消化道症状,防止消化道出血,从而缩短病程。

Objective：To observe the adjunctive effect of the viable organism praeparatum Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines-Live（Medilac-Vita） in the treatment of henoch purpura in children.Methods： Together 139 children with henoch purpura as research subjects were divided into observation group and control group by random number table method.In the control group,children were treated with cimetidine,vitamin C,calcium,glucocorticosteroid;and antibiotics therapy was given to those who had combined infection.The observation group were given Medilac-Vita in addition to the same treatment as the control group.Aged 4~6 years,1 g each time;aged ~12 years,1.5 g each time;all three times a day,7 days as a course of treatment.The symptom changes of digestive tube（stomachache,emesia,hemafecia）,levels of salivary secretary IgA（sIgA） and clinical effect after treatment in 1 week of the two groups were observed.Results： The extinction time of digestive tube symptoms in observation group was less than that of the control group（P0.05）.The sIgA was increased significantly in the observation group after treatment in 1 week（t=4.556,P0.01）,but there was no significant changes in the control group（t=0.914,P0.05）.The total effective rate in observation group was 95.71%,while that of the control group was 81.82%,there was significant difference in the two groups（χ2=4.978,P0.05）.Conclusions： Viable organism praeparatum Medilac-Vita can enhance the immunity of mucous membrane.In the treatment of henoch purpura in children,it can relieve digestive tube symptoms quickly,prevent alimentary tract hemorrhage,and shorten the course of treatment.