低渗口服补液盐在小儿轮状病毒肠炎中的临床应用

Application of Oral Rehydration Salt in Children with Rotavirus Enteritis

目的:探讨口服补液盐散Ⅲ(ORSⅢ)治疗小儿轮状病毒肠炎所致轻、中度脱水患儿的疗效和安全性。方法:156例患儿随机分为治疗组80例和对照组76例,两组在抗病毒、调理胃肠功能、调整饮食、适当止泻等基础上,治疗组给予ORSⅢ口服,对照组予口服补液盐散Ⅱ(ORSⅡ)口服,观察两组腹泻、呕吐及脱水改善情况,24 h、48 h、72 h血钠监测。结果:治疗组有效77例,无效3例;对照组有效67例,无效9例,两组比较差异有统计学意义(χ2=3.95,P<0.05)。治疗组平均病程(4.7±1.3)d,脱水纠正时间(1.1±0.5)d;对照组平均病程(6.2±1.5)d,脱水纠正时间(1.5±0.7)d,两组比较差异有统计学意义(u=5.65、6.52,P均<0.05)。两组24 h、48 h、72 h血钠监测结果比较差异无统计学意义(P>0.05)。结论:ORSⅢ、ORSⅡ为临床治疗轮状病毒肠炎轻、中度脱水较好的补液方法,只要调配服用得当不会发生高钠血症、低钠血症、水肿等副作用,但ORSⅢ在改善临床症状、缩短病程方面优于ORSⅡ。

Objective： To discuss the effects and safety of Oral Rehydration Salt Ⅲ（ORS Ⅲ） applied to children with rotavirus enteritis.Methods： Together 156 cases（children who suffered from rotavirus enteritis） were divided into a treatment group（80 cases） and a control group（76 cases）.Both groups were treated with antibiotics,and regulated their gastrointestinal functions and diets to stop diarrhea.The treatment group received ORS Ⅲ,while the control group was given ORS Ⅱ.Their symptoms of diarrhea,vomiting and dehydration were observed.Their blood sodium in 24 h,48 h and 72 h were monitored.Results： The effective number of the treatment group was 77 cases,ineffective number was 3 cases and the comparison group was 67 and 9.The numbers of the two groups had statistical significance（χ2=3.95,P0.05）.The average treatment course of the first group was（4.7±1.3） days,and the course of reducing dehydration was（1.1± 0.5） days,while that of the control group was（6.2±1.5） days and（1.5±0.7） days,respectively.The differences also had statistical significance（u=5.65,6.52,P0.05）.The differences of blood sodium concentrations at 24 h,48 h and 72 h between the two groups had no statistical significance（P0.05）.Conclusions： ORS Ⅲ and ORS Ⅱ are effective drugs to cure rotavirus enteritis.If prepared and taken properly,they will not cause hypernatremia,hyponatremia and edema.ORS Ⅲ has advantages over ORS Ⅱ in improving the clinical symptoms and reducing the treatment course.