盐酸氨溴索雾化吸入辅助治疗新生儿肺炎临床观察

The Clinical Observation of Inhalation Ambroxol as Adjunctive Therapy in Neonatal Pneumonia

目的:探讨盐酸氨溴索雾化吸入辅助治疗新生儿肺炎的疗效。方法:将60例新生儿肺炎患儿随机分为两组各30例,对照组采用常规抗感染、吸氧、吸痰等治疗,治疗组在对照组常规治疗基础上给予氨溴索30 mg电动压缩雾化吸入,2～3次/d。结果:治疗组总有效率90.0%,明显优于对照组的63.3%(P<0.01),治疗组血气分析恢复正常时间为(3.50±1.29)d、肺部啰音消失时间(6.23±2.31)d、住院天数(9.51±3.23)d,均较对照组的(6.12±2.35)d、(9.15±3.14)d、(11.00±4.67)d明显缩短,两组比较差异均有统计学意义(P<0.01)。结论:盐酸氨溴索雾化吸入辅助治疗新生儿肺炎具有良好疗效和安全性。

Objective： To investigate the curative effect of ambroxol hydrochloride supporting the treatment of neonatal pneumonia.Methods： Sixty cases of newborns undergoing pneumonia were randomly divided into two groups with 30 patients in each group.Conventional anti-infection,oxygen therapy,sputum suction were administered to the control group,and the therapy group was treated with inhalation ambroxol 30 mg,2~3 times/d,based on the conventional treatment.Results： The total effective rate of the treatment group（90.0%） was significantly higher than that of the control group（63.3%）（χ2=5.96,P0.01）,and the recovery time of blood gases parameters（3.50±1.29）days,the relief time of pulmonary rale（6.23±2.31）days,and the length of hospital-stay（9.51±3.23）days in the therapy group were significantly shorter than those in the control group [（6.12±2.35）days,（9.15±3.14）days,（11.00±4.67）days]（P0.01）.Conclusions： The inhalation ambroxol is a safe and valid adjunctive therapy in neonatal pneumonia.