犬下颌骨骨缺损自我修复能力的电镜观察

Canine mandibular bone defect:electron microscopic observation of its self-healing

目的探讨不同范围颌骨骨缺损区的自我修复能力。方法在实验犬的下颌骨上形成深5 mm、高(颊舌向)5 mm及宽(近远中向)分别为1、2、3、4、5 mm的骨缺损区(各缺损区间距为6 mm)的标准梯度骨缺损,直接拉拢缝合。术后12周处死动物,取缺损区骨段进行扫描电镜观察。结果水平宽度为1、2、3 mm骨缺损组,骨缺损区域均由较多新生骨充满。4、5 mm骨缺损区基本无新生骨形成,多为结缔软组织成分。结论 3 mm以下的骨缺损区12周时有良好新骨形成,与原有正常骨质相比较为接近,该范围以下的骨缺损可在无外界干预的条件下进行自我修复。

Objective To investigate the self-repair capacity of different bone defect sizes on the mandible.Methods On both side of dog＇s mandible bones,bone defects which were 5 mm in length,5 mm in depth and 1,2,3,4,5 mm in width were respectively made.Then,direct suture was performed.Three months after the operation,segments of bone defects were observed with scanning electron microscope.Results The bone defects,which were 1,2,3 mm in width were basically full of new bone.However,the defects of 4 and 5 mm had almost no new bone formation,mainly fibrous soft tissue composition instead.Conclusion For defects less than 3mm in width,the bone defect area has good new bone formation,so under this circumstance,it is not necessary to use guided-issue regeneration or other interventions.