小剂量丙种球蛋白联合糖皮质激素治疗成人特发性血小板减少性紫癜22例疗效分析

Clinical analysis of low-dose intravenous immunoglobulin combined with glucocorticoids on treating 22 adult cases of idiopathic thrombocytopenic purprua

目的探讨糖皮质激素联合小剂量丙种球蛋白治疗成人特发性血小板减少性紫癜的临床疗效。方法将该科2004年1月至2010年6月收治的急性、重症特发性血小板减少性紫癜患者45例,按随机数字表法分为常规剂量组(23例)和小剂量组(22例),常规剂量组静脉注射大剂量丙种球蛋白联合糖皮质激素治疗,小剂量组静脉注射小剂量丙种球蛋白联合糖皮质激素治疗,比较两种不同方案的治疗效果。结果常规剂量组患者显效(43.5%)、有效(34.8%)比小剂量组(40.9%、31.8%)高,差异有统计学意义(P<0.05)。结论小剂量静脉注射丙种球蛋白联合糖皮质激素在治疗成人特发性血小板减少性紫癜有与常规治疗相同的疗效,且花费少、安全性高。

Objective To investigate the effectiveness of low-dose intravenous immunoglobulin（IVIG）combined with glucocorticoids for treating adult idiopathic thrombocytopenic purprua（ITP）.Methods 45 patients with acute severe ITP in our department from January 2004 to June 2010 were randomly divided into two group：routine high-dose IVIG combined with glucocorticoids group（23 cases）and low-dose IVIG combined with glucocorticoids group（22 cases）.The clinical results were compared between the two groups.Results The excellent effective rate and the effective rate were 43.5% and 34.8% in the routine dose group and 40.9% and 31.8% in the low dose group,showing no significant difference between the two groups（P0.05）.Conclusion Low-dose intravenous immunoglobulin combined with glucocorticoids for treating adult ITP has the same curative effect as traditional therapy with low costs and high safety.